bc7b00749_si_001.pdf (734.09 kB)
Synthesis and Characterization of Nitric Oxide-Releasing Platinum(IV) Prodrug and Polymeric Micelle Triggered by Light
journal contribution
posted on 2017-12-27, 00:00 authored by Swapan Pramanick, Jihoon Kim, Jinhwan Kim, Gurusamy Saravanakumar, Dongsik Park, Won Jong KimHerein, we report the proof of concept
of photoresponsive chemotherapeutics
comprising nitric oxide-releasing platinum prodrugs and polymeric
micelles. Photoactivatable nitric oxide-releasing donors were integrated
into the axial positions of a platinum(IV) prodrug, and the photolabile
hydrophobic groups were grafted in the block copolymers. The hydrophobic
interaction between nitric oxide donors and the photolabile groups
allowed for the loading of platinum drugs and nitric oxide-releasing
donors in the photolabile polymeric micelles. After cellular uptake
of micelles, light irradiation induced the release of nitric oxide,
which sensitized the cancer cells. Simultaneously, photolabile hydrophobic
groups were cleaved from micelles, and the nitric oxide-releasing
donor was altered to be more hydrophilic, resulting in the rapid release
of platinum(IV) prodrugs. The strategy of using platinum(IV) prodrugs
and nitric oxide led to enhanced anticancer effects.