jp0527507_si_001.pdf (20.36 kB)
Spectrophotometric Study of Fluorescence Sensing and Selective Binding of Biochemical Substrates by 2,2‘-Bridged Bis(β-cyclodextrin) and Its Water-Soluble Fullerene Conjugate
journal contribution
posted on 2005-12-15, 00:00 authored by Yu Liu, Peng Liang, Yong Chen, Yan-Li Zhao, Fei Ding, Ao YuA bis(β-cyclodextrin)−fullerene conjugate (3) linked at the secondary hydroxyl side was prepared in a good
yield from its precursor N,N‘-bis(2-(2-aminoethylamino)ethyl)malonamide-bridged bis(β-cyclodextrin) (2).
Spectrophotomeric studies on the conformation and the inclusion complexation behavior of 3 with a variety
of organic and biochemical substrates by means of UV−vis, FT-IR, NMR, fluorescence, and circular dichroism
spectroscopy showed that the bis(β-cyclodextrin)−fullerene conjugate displayed an intramolecular capsule-type conformation in aqueous solution. Because of the multiple binding of bis(β-cyclodextrin) with substrates,
2 can act as an efficient fluorescence sensor for biochemical substrates, while its fullerene conjugate 3 displays
a capability of cleaving DNA under visible-light irradiation.