bc8b00706_si_001.pdf (291.13 kB)
Small Synthetic Peptides Bioconjugated to Hybrid Gold Nanoparticles Destroy Potentially Deadly Bacteria at Submicromolar Concentrations
journal contribution
posted on 2018-10-23, 00:00 authored by Gianna Palmieri, Rosarita Tatè, Marta Gogliettino, Marco Balestrieri, Ilaria Rea, Monica Terracciano, Yolande Therese Proroga, Federico Capuano, Aniello Anastasio, Luca De StefanoSynthetic antibacterial peptides
are advanced weapons that scientists
design and produce to confront current threats of harmful and mortal
pathogens, which could affect humans in everyday life. Recently, many
small amino acid sequences, greatly efficient in their antibacterial
action, have been reported in the literature. To date, only a few
synthetic peptides, acting at micromolar or even tenths of micromolar
concentrations, are on the market as commercial products, mainly because
of their high cost of production. In this context, materials science
can provide fundamental help by engineering small synthetic peptides,
powered by hybrid gold nanoparticles, which have been found to strongly
enhance antimicrobial activity against bacterial infections. Submicromolar
concentrations of the 1018K6 peptide, bioconjugated to hybrid polymer–gold
nanoparticles, kill almost 100% of pathogen bacteria, such as Listeria and Salmonella genera, paving
the way for economically sustainable commercial products based on
this synthetic nanocomplex.