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Polylactide-Based Chiral Porous Monolithic Materials Prepared Using the High Internal Phase Emulsion Template Method for Enantioselective Release
journal contribution
posted on 2019-09-13, 11:04 authored by Xueyong Yong, Qisong Hu, Ergang Zhou, Jianping Deng, Youping WuPolylactide
[PLA, two enantiomers: poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA)] has been widely applied as biomaterials because
of its biocompatibility, biodegradability, and good mechanical capacity.
However, the chirality of PLA materials has not been intensively explored
yet. In the present study, chiral porous poly(high internal-phase
emulsion)s (polyHIPEs) derived from enantiopure PLAs were successfully
prepared via a HIPE template method. The resulting polyHIPEs show
optical activity. More interestingly, the polyHIPEs demonstrate enantioselective
release capacity, using cinchona alkaloid and naproxen as the model
chiral drugs. Notably, PLLA-based polyHIPE shows enantioselectivity
in both the drug-loading step and drug-releasing step, while PDLA-based
polyHIPE fails. The interesting finding is essentially different from
other chiral polymer materials reported earlier. The cytotoxicity
test demonstrates that all the three types of polyHIPEs, PLLA-, PDLA-,
and PDLLA-based polyHIPE show biocompatibility; however, their different
chirality exerts varying effects on cell growth. Accordingly, special
attention should be devoted to the chirality of PLA when used as biomaterials.
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cinchona alkaloidmodel chiral drugsPLA materialsdrug-loading stepHigh Internal Phase Emulsion Template MethodPolylactide-Based Chiral Porous Monolithic Materialsenantiopure PLAschiralitycytotoxicity testPLLA-based polyHIPEchiral polymer materialsenantioselective release capacityPDLA-based polyHIPEHIPE template methodcell growthpolyHIPEs showdrug-releasing stepEnantioselective Release PolylactidePDLLA-based polyHIPE show biocompatibility
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