Palladium-Catalyzed Methylation of Aryl C−H Bond by Using Peroxides

Zhang, Yuhua; Feng, Jianqing; Li, Chao-Jun

doi:10.1021/ja0775063.s003

ja0775063_si_003.pdf (1.13 MB)

Palladium-Catalyzed Methylation of Aryl C−H Bond by Using Peroxides

journal contribution

posted on 2008-03-12, 00:00 authored by Yuhua Zhang, Jianqing Feng, Chao-Jun Li

A novel Pd(OAc)₂-catalyzed methylation reaction by dicumyl peroxide via aryl C−H bond activation was discovered. Various 2-phenylpyridine and acetanilides can be used as reactants in these reactions. Peroxide was used as both the methylating reagent and the hydrogen acceptor.