ol6b01027_si_001.pdf (3.27 MB)
One-Step Synthesis of Diverse Pyridine-Containing Heterocycles with 3‑Ethoxycyclobutanones at Room Temperature
journal contribution
posted on 2016-04-26, 15:36 authored by Yun Lin, Xinglin Yang, Weidong Pan, Yu RaoAn
efficient and convenient approach toward a diversity-oriented synthesis
of bioactive pyridine-containing fused heterocycles is described.
Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with
various heterocyclic amines, a broad range of heterocyclic compounds
were prepared readily at ambient temperature with excellent regioselectivity.