One-Step Synthesis of Diverse Pyridine-Containing Heterocycles with 3‑Ethoxycyclobutanones at Room Temperature

An efficient and convenient approach toward a diversity-oriented synthesis of bioactive pyridine-containing fused heterocycles is described. Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with various heterocyclic amines, a broad range of heterocyclic compounds were prepared readily at ambient temperature with excellent regioselectivity.