One-Pot Aqueous Synthesis of Icosahedral Au as Bifunctional Candidates for Enhanced Glucose Electrooxidation and Surface-Enhanced Raman Scattering

Bifunctional candidates, which could provide catalytic and plasmonic properties simultaneously, could activate a promising development for biomedicine. Here, we kinetically controlled and synthesized a penta-twinned icosahedral Au (Ih Au) by a facile wet-chemical protocol without assistance of stabilizers. Benefiting from icosahedral morphology and kinetic synthesis process, the Ih Au nanoparticles (NPs) incorporate three key advantages: (i) ample active sites/“hot spots” and surface strain, (ii) good stability/chemical inertness and easy functionalization, and (iii) biological compatibility and a clean surface, which could promote their electrocatalysis and photonic capacity. Ih Au NPs, as bifunctional nanomaterials, exert excellent electrocatalytic and surface-enhanced Raman scattering (SERS) performances. Ih Au delivers the highest glucose electrooxidation (GEO) peak current density with 6.87 mA cm^–2, which is 14 times larger than that of Turkevich Au (0.49 mA cm^–2) under the same condition. Moreover, the SERS signals of rhodamine 6G (R6G) on Ih Au are much stronger than that on the other corresponding Au counterparts. Particularly, the SERS intensity of R6G on Ih Au increases by about four times compared to that on Au NPs. This study motivates the great prospect for combining Ih Au’s bifunctionalities and indicates the potential of bifunctional nanomaterials in biologically implanted devices.