jf8b03772_si_001.pdf (5.31 MB)
Neolignan Constituents with Potential Beneficial Effects in Prevention of Type 2 Diabetes from Viburnum fordiae Hance Fruits
journal contribution
posted on 2018-09-19, 00:00 authored by Chunchao Zhao, Jia Chen, Jianhua Shao, Jie Shen, Kehuan Li, Wenyan Gu, Sihui Li, Judi FanNine
new neolignan glycosides (1–9), viburfordosides
A–I, two new neolignans, fordianes A and
B (10, 11), and seven known analogues (12–18) have been isolated and identified
from the fruits of Viburnum fordiae Hance. The structures and absolute configurations of undescribed
neolignan constituents were identified by chemical methods and spectroscopic
analyses. The α-glucosidase inhibitory, ABTS•+ and DPPH• scavenging, and anti-inflammatory activities
of these secondary metabolites were evaluated. Some of them exhibited
significant potency in inhibiting α-glucosidase and scavenging
free radicals. Among the 14 metabolites that were found to have the
capacity to inhibit NO production in LPS-stimulated RAW264.7 macrophage
cells, compounds 2, 4, 6, 10, 11, 14, 17, and 18 were potent with IC50 values of 10.88–41.10
μM. These results support that V. fordiae fruits possessing the neolignan compounds may serve as both a functional
food and a medicinal resource to prevent and treat type 2 diabetes
(T2D).