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Highly Enantioselective Hydrogenation of Enamides Catalyzed by Chiral Phosphoric Acids
journal contribution
posted on 2009-03-05, 00:00 authored by Guilong Li, Jon C. AntillaA highly enantioselective hydrogenation of enamides catalyzed by a dual chiral−achiral acid system was developed. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, catalyst loadings as low as 1 mol % of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product.