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Effect of Solvent Quality on the Solution Properties of Assemblies of Partially Fluorinated Amphiphilic Diblock Copolymers
journal contribution
posted on 2012-11-13, 00:00 authored by Hui Peng, Kristofer
J. Thurecht, Idriss Blakey, Elena Taran, Andrew K. WhittakerThe effect of solvent on the formation of assemblies
of partially
fluorinated block copolymers in solution has been examined. Two classes
of materials based respectively on 2,2,2-trifluoroethyl acrylate (TFEA)
and 2,2,2-trifluoroethyl methacrylate (TFEMA) were dissolved in organic
solvents, and the properties on successive addition of water were
studied using NMR spectroscopy, NMR imaging, AFM, and TEM. The relatively
high glass transition temperature of the methacrylate blocks resulted
in the formation of kinetically trapped structures that could only
be resolved following heating to temperatures well above the Tg. The acrylate polymers formed loose assemblies
in pure dimethylformamide, and on addition of water cylindrical micelles
were observed. On the other hand, in pure acetone the partially fluorinated
segments interacted more strongly with the solvent, with this structure
inverting on addition of water. The NMR parameters were strongly dependent
on the proposed structures in solution, and most markedly the mutual
association of the fluorinated segments resulted in strong dipole–dipole
interactions with the 19F spins. The importance of structure
and solvent on the potential of these copolymers as MRI contrast agents
is discussed, and broad design rules for effective 19F
MRI agents are given.
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structure invertingNMR parameterstrifluoroethylmethacrylate blocksacrylate polymersSolvent Qualitydesign rules19 FTFEA19 F MRI agentsTFEMAglass transition temperaturesegments interactedNMR spectroscopyAFMassemblyMRI contrast agentsblock copolymersformationTEMPartially Fluorinated Amphiphilic Diblock CopolymersThe effectNMR imagingsolutionSolution Properties
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