ac0c00634_si_001.pdf (2.86 MB)
Design of Activatable NIR-II Molecular Probe for In Vivo Elucidation of Disease-Related Viscosity Variations
journal contribution
posted on 2020-03-05, 21:44 authored by Kun Dou, Weijing Huang, Yunhui Xiang, Songjiao Li, Zhihong LiuA clear elucidation
of a disease-related viscosity change in vivo
is significant yet highly challenging as well. Fluorescence imaging
in the second near-infrared region (NIR-II, 1000–1700 nm) has
gained increasing attention for observation in living organisms, but
a viscosity-activatable fluorescent probe emitting at this region
remains a vacancy. Herein, we report the first panel of a viscosity-activated
NIR-II emissive fluorescent probe WD-X. By embedding
different substituents into the WD-X platform and screening,
we obtained an ideal probe, WD-NO2, which displayed the best combination of properties, including a
31-fold fluorescence enhancement in response to viscosity, insensitivity
to environments (pH, polarity), and relatively high quantum yield
(1.6% in glycerol). WD-NO2 was
successfully applied to track the variation of viscosity in diabetes-induced
liver injury in vivo.