Cu(I)-Catalyzed Enantioselective [3 + 2]
Cycloaddition Reaction of
1-Alkylallenylsilane with α-Imino Ester: 
Asymmetric Synthesis of
Dehydroproline Derivatives

Daidouji, Kazunori; Fuchibe, Kohei; Akiyama, Takahiko

doi:10.1021/ol047343c.s003

ol047343c_si_003.pdf (7.87 MB)

Cu(I)-Catalyzed Enantioselective [3 + 2] Cycloaddition Reaction of 1-Alkylallenylsilane with α-Imino Ester: Asymmetric Synthesis of Dehydroproline Derivatives

journal contribution

posted on 2005-03-17, 00:00 authored by Kazunori Daidouji, Kohei Fuchibe, Takahiko Akiyama

The catalytic, enantioselective [3 + 2] cycloaddition reaction of 1-alkyl-substituted allenylsilanes with α-imino ester has been achieved by means of [Cu(MeCN)₄]BF₄/(R)-DM-SEGPHOS catalyst to afford silyl-substituted dehydroproline derivatives in high yields and enantioselectivities.