ol4036177_si_001.pdf (1.22 MB)
Concise synthesis of Didebromohamacanthin A and Demethylaplysinopsine: Addition of Ethylenediamine and Guanidine Derivatives to the Pyrrole-Amino Acid Diketopiperazines in Oxidative Conditions
journal contribution
posted on 2014-02-07, 00:00 authored by Ludmila Ermolenko, Hu Zhaoyu, Clarisse Lejeune, Carine Vergne, Céline Ratinaud, Thanh Binh Nguyen, Ali Al-MourabitOxidative
nucleophilic addition of ethylenediamine and guanidine derivatives
to pyrrole-amino acid diketopiperazines was shown to provide substituted
5,6-dihydro-2(1H)-piperazinones, quinoxalinones,
and 2-aminoimidazolones. On the basis of this methodology, a concise
approach to natural products didebromohamacanthin A and demethylaplysinopsine
has been demonstrated.
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demethylaplysinopsineDidebromohamacanthinguanidine derivativesacidConcise synthesisGuanidine DerivativesmethodologyapproachDiketopiperazineEthylenediamineproducts didebromohamacanthindiketopiperazineOxidative ConditionsOxidative nucleophilic additionaminoimidazolonebasisethylenediamineDemethylaplysinopsinequinoxalinonedihydro
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