ma9b02595_si_001.pdf (46.44 MB)
Blended Assemblies of Amphiphilic Random and Block Copolymers for Tunable Encapsulation and Release of Hydrophobic Guest Molecules
journal contribution
posted on 2020-03-19, 19:16 authored by Ziwen Jiang, Hongxu Liu, Huan He, Alexander E. Ribbe, S. ThayumanavanSelf-assembly
of amphiphilic polymers in aqueous solution builds
up versatile carrier platforms for therapeutic delivery. Amphiphilic
polymers specifically provide “hydrophobic pockets”
for the encapsulation of water-insoluble small-molecule drugs, along
with effective strategies to control the cargo release. Random and
block copolymers have been separately demonstrated to affect the cargo
encapsulation and release. In this study, we present self-assembled
structures of blended random and block copolymers to tune the encapsulation
and release of lipophilic cargo molecules. The hydrophilic–lipophilic
balance (HLB) within the polymeric (co-)assemblies greatly affects
their cargo loading capacity. Meanwhile, the disulfide moieties within
the polymeric assemblies allow controlled cargo release upon a redox
stimulus such as glutathione. The triggered release of encapsulated
cargos is affected by the overall HLB, the reactivity, and accessibility
of the disulfide species within the polymeric assemblies.