Appending a Tris-imidazole Ligand with a Tyr<sup>244</sup> Mimic on the Distal Face of Bromoacetamidoporphyrin
2004-03-18T00:00:00Z (GMT) by
Bromoacetamidoporphyrin is a convenient synthon for the attachment of distal superstructures at room temperature in good yields. New models are presented that contain a tris-imidazole distal ligand set bound to the porphyrin in either a binary or trinary fashion. More importantly, one distal imidazole is cross-linked to a phenol mimicking Tyr<sup>244</sup>, making this model the closest structural analogue yet reported of the metal free cytochrome <i>c</i> oxidase (C<i>c</i>O) active site.