ol049912m_si_001.pdf (4.54 MB)
Appending a Tris-imidazole Ligand with a Tyr244 Mimic on the Distal Face of Bromoacetamidoporphyrin
journal contribution
posted on 2004-03-18, 00:00 authored by James P. Collman, Richard A. Decréau, Simona CostanzoBromoacetamidoporphyrin is a convenient synthon for the attachment of distal superstructures at room temperature in good yields. New
models are presented that contain a tris-imidazole distal ligand set bound to the porphyrin in either a binary or trinary fashion. More importantly,
one distal imidazole is cross-linked to a phenol mimicking Tyr244, making this model the closest structural analogue yet reported of the metal
free cytochrome c oxidase (CcO) active site.