ol901441t_si_001.pdf (2.56 MB)
An Asymmetric Hetero-Claisen Approach to 3-Alkyl-3-aryloxindoles
journal contribution
posted on 2009-09-03, 00:00 authored by Nicolas Duguet, Alexandra M. Z. Slawin, Andrew D. SmithThe reaction of a chiral N-phenylnitrone derived from Garner’s aldehyde with alkylarylketenes generates 3-alkyl-3-aryloxindoles directly in excellent yields and with good to excellent levels of enantioselectivity (up to 90% ee).
