np9b00840_si_001.pdf (1.56 MB)
Albanitriles A–G: Antiprotozoal Polyacetylene Nitriles from a Mycale Marine Sponge
journal contribution
posted on 2019-12-12, 21:13 authored by Samuele Sala, Jane Fromont, Oliver Gomez, Daniel Vuong, Ernest Lacey, Gavin R. FlemattiSeven new nitrile-bearing polyacetylenes, named albanitriles
A–G,
were isolated from a marine sponge of the Mycale genus
(Order: Poecilosclerida, Family: Mycalidae) collected near Albany,
Western Australia. Structural elucidation was achieved using a combination
of high-resolution mass spectrometry and ultraviolet/visible, infrared,
and nuclear magnetic resonance spectroscopy. The compounds were found
to possess moderate activity against Giardia duodenalis when compared to a metronidazole positive control.