ol0c00600_si_001.pdf (7.85 MB)
Access to N‑Carbonyl Derivatives of Iminosydnones by Carbonylimidazolium Activation
journal contribution
posted on 2020-03-10, 19:43 authored by Margaux Riomet, Karine Porte, Léa Madegard, Pierre Thuéry, Davide Audisio, Frédéric TaranA new
methodology for N-exocyclic functionalization
of iminosydnones was developed involving the addition of a large variety
of nucleophiles on carbonyl-imidazolium-activated iminosydnones. This
practical and highly versatile method provided access to new classes
of iminosydnones and opened a straightforward synthetic route to prepare
iminosydnone-based prodrugs.