1,4-Palladium Shift/C(sp3)–H Activation Strategy for the Remote Construction of Five-Membered Rings

2019-02-08T19:50:26Z (GMT) by Ronan Rocaboy Olivier Baudoin
1,n-Metal shift is an elegant alternative approach enabling the functionalization of remote C–H bonds from simple precursors. In this work, we report a novel and simple Pd0-catalyzed domino reaction involving 1,4-palladium shift and C­(sp3)–H activation and leading to (fused) five-membered rings. This method allowed access to a broad range of valuable arylidene γ-lactams and indanones and was applied to the formal synthesis of (−)-pyrrolam.