data_hmc9907 _audit_creation_method SHELXL-97 _chemical_name_systematic ; ? ; _chemical_name_common ? _chemical_formula_moiety ? _chemical_formula_sum 'C76 H48 O12' _chemical_formula_weight 1153.14 loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source 'C' 'C' 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' 'H' 'H' 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' 'O' 'O' 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _symmetry_cell_setting Monoclinic _symmetry_space_group_name_H-M C2/c loop_ _symmetry_equiv_pos_as_xyz 'x, y, z' 'x, -y, z+1/2' 'x+1/2, y+1/2, z' 'x+1/2, -y+1/2, z+1/2' '-x, -y, -z' '-x, y, -z-1/2' '-x+1/2, -y+1/2, -z' '-x+1/2, y+1/2, -z-1/2' _cell_length_a 24.637(5) _cell_length_b 14.6342(7) _cell_length_c 17.525(3) _cell_angle_alpha 90.00 _cell_angle_beta 114.067(14) _cell_angle_gamma 90.00 _cell_volume 5769.3(15) _cell_formula_units_Z 4 _cell_measurement_temperature 293(2) _cell_measurement_reflns_used 25 _cell_measurement_theta_min 11.2 _cell_measurement_theta_max 24.8 _exptl_crystal_description Plates _exptl_crystal_colour Colourless _exptl_crystal_size_max .32 _exptl_crystal_size_mid .32 _exptl_crystal_size_min .08 _exptl_crystal_density_meas ? _exptl_crystal_density_diffrn 1.328 _exptl_crystal_density_method 'not measured' _exptl_crystal_F_000 2400 _exptl_absorpt_coefficient_mu 0.729 _exptl_absorpt_correction_type none _exptl_absorpt_correction_T_min ? _exptl_absorpt_correction_T_max ? _exptl_special_details ; ? ; _diffrn_ambient_temperature 293(2) _diffrn_radiation_wavelength 1.54178 _diffrn_radiation_type CuK\a _diffrn_radiation_source 'fine-focus sealed tube' _diffrn_radiation_monochromator graphite _diffrn_measurement_device_type ? _diffrn_measurement_method ? _diffrn_detector_area_resol_mean ? _diffrn_standards_number ? _diffrn_standards_interval_count ? _diffrn_standards_interval_time ? _diffrn_standards_decay_% ? _diffrn_reflns_number 4360 _diffrn_reflns_av_R_equivalents 0.0202 _diffrn_reflns_av_sigmaI/netI 0.0242 _diffrn_reflns_limit_h_min -13 _diffrn_reflns_limit_h_max 28 _diffrn_reflns_limit_k_min -16 _diffrn_reflns_limit_k_max 11 _diffrn_reflns_limit_l_min -19 _diffrn_reflns_limit_l_max 20 _diffrn_reflns_theta_min 3.60 _diffrn_reflns_theta_max 61.96 _reflns_number_total 4242 _reflns_number_gt 3228 _reflns_threshold_expression >2sigma(I) _computing_data_collection ? _computing_cell_refinement ? _computing_data_reduction ? _computing_structure_solution 'SHELXS-97 (Sheldrick, 1990)' _computing_structure_refinement 'SHELXL-97 (Sheldrick, 1997)' _computing_molecular_graphics ? _computing_publication_material ? _refine_special_details ; Refinement of F^2^ against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F^2^, conventional R-factors R are based on F, with F set to zero for negative F^2^. The threshold expression of F^2^ > 2sigma(F^2^) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F^2^ are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. ; _refine_ls_structure_factor_coef Fsqd _refine_ls_matrix_type full _refine_ls_weighting_scheme 'calc w=1/[\s^2^(Fo^2^)+(0.0600P)^2^+3.8199P] where P=(Fo^2^+2Fc^2^)/3' _atom_sites_solution_primary direct _atom_sites_solution_secondary difmap _atom_sites_solution_hydrogens geom _refine_ls_hydrogen_treatment mixed _refine_ls_extinction_method SHELXL _refine_ls_extinction_coef 0.00083(6) _refine_ls_extinction_expression 'Fc^*^=kFc[1+0.001xFc^2^\l^3^/sin(2\q)]^-1/4^' _refine_ls_number_reflns 4242 _refine_ls_number_parameters 400 _refine_ls_number_restraints 0 _refine_ls_R_factor_all 0.0678 _refine_ls_R_factor_gt 0.0497 _refine_ls_wR_factor_ref 0.1402 _refine_ls_wR_factor_gt 0.1259 _refine_ls_goodness_of_fit_ref 1.037 _refine_ls_restrained_S_all 1.037 _refine_ls_shift/su_max 0.001 _refine_ls_shift/su_mean 0.000 loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_calc_flag _atom_site_refinement_flags _atom_site_disorder_assembly _atom_site_disorder_group C1 C 0.0000 0.0331(3) 0.2500 0.0693(10) Uani 1 d S . . O1 O 0.0000 -0.0507(2) 0.2500 0.0998(11) Uani 1 d S . . C2 C 0.04973(11) 0.08198(18) 0.31667(17) 0.0645(7) Uani 1 d . . . C3 C 0.06860(12) 0.16924(19) 0.30783(17) 0.0710(8) Uani 1 d . . . H3A H 0.0484 0.2017 0.2587 0.085 Uiso 1 calc R . . C4 C 0.11730(13) 0.2084(2) 0.37146(17) 0.0751(8) Uani 1 d . . . H4A H 0.1296 0.2669 0.3650 0.090 Uiso 1 calc R . . C5 C 0.14744(12) 0.16092(19) 0.44409(16) 0.0662(7) Uani 1 d . . . C6 C 0.12904(12) 0.0754(2) 0.45469(18) 0.0750(8) Uani 1 d . . . H6A H 0.1489 0.0439 0.5045 0.090 Uiso 1 calc R . . C7 C 0.08100(11) 0.0366(2) 0.39114(19) 0.0750(8) Uani 1 d . . . H7A H 0.0692 -0.0220 0.3984 0.090 Uiso 1 calc R . . O8 O 0.19494(8) 0.20516(13) 0.50480(12) 0.0787(6) Uani 1 d . . . C9 C 0.23899(12) 0.15445(19) 0.56583(15) 0.0640(7) Uani 1 d . . . C10 C 0.25285(15) 0.1747(2) 0.64874(17) 0.0826(9) Uani 1 d . . . H10A H 0.2308 0.2181 0.6626 0.099 Uiso 1 calc R . . C11 C 0.29947(14) 0.1305(2) 0.71094(16) 0.0842(9) Uani 1 d . . . H11A H 0.3088 0.1446 0.7666 0.101 Uiso 1 calc R . . C12 C 0.33172(13) 0.0669(2) 0.69172(16) 0.0758(8) Uani 1 d . . . H12A H 0.3627 0.0368 0.7341 0.091 Uiso 1 calc R . . C13 C 0.31868(12) 0.04669(19) 0.60907(15) 0.0668(7) Uani 1 d . . . H13A H 0.3412 0.0037 0.5957 0.080 Uiso 1 calc R . . C14 C 0.27245(11) 0.09022(17) 0.54675(13) 0.0586(6) Uani 1 d . . . O15 O 0.26056(9) 0.07698(12) 0.46280(9) 0.0682(5) Uani 1 d . . . C16 C 0.23863(11) -0.00610(17) 0.42585(13) 0.0566(6) Uani 1 d . . . C17 C 0.23550(12) -0.08380(18) 0.46805(14) 0.0639(7) Uani 1 d . . . H17A H 0.2491 -0.0834 0.5260 0.077 Uiso 1 calc R . . C18 C 0.21200(11) -0.16207(17) 0.42320(14) 0.0620(7) Uani 1 d . . . H18A H 0.2098 -0.2147 0.4515 0.074 Uiso 1 calc R . . C19 C 0.19144(10) -0.16430(17) 0.33662(14) 0.0571(6) Uani 1 d . . . C20 C 0.19531(11) -0.08457(17) 0.29602(14) 0.0604(6) Uani 1 d . . . H20A H 0.1814 -0.0844 0.2381 0.073 Uiso 1 calc R . . C21 C 0.21921(12) -0.00609(18) 0.33964(14) 0.0627(7) Uani 1 d . . . H21A H 0.2223 0.0464 0.3118 0.075 Uiso 1 calc R . . C22 C 0.17082(11) -0.25191(18) 0.29168(15) 0.0623(7) Uani 1 d . . . O22 O 0.19256(9) -0.32425(13) 0.32421(12) 0.0853(7) Uani 1 d . . . C23 C 0.12411(11) -0.24972(16) 0.20473(14) 0.0577(6) Uani 1 d . . . C24 C 0.12639(12) -0.31117(18) 0.14604(17) 0.0678(7) Uani 1 d . . . H24A H 0.1572 -0.3535 0.1612 0.081 Uiso 1 calc R . . C25 C 0.08343(12) -0.31019(18) 0.06517(17) 0.0689(7) Uani 1 d . . . H25A H 0.0864 -0.3490 0.0250 0.083 Uiso 1 calc R . . C26 C 0.03610(11) -0.25101(19) 0.04467(15) 0.0629(7) Uani 1 d . . . C27 C 0.03228(11) -0.19046(19) 0.10217(15) 0.0635(7) Uani 1 d . . . H27A H 0.0000 -0.1510 0.0877 0.076 Uiso 1 calc R . . C28 C 0.07712(11) -0.18899(17) 0.18185(14) 0.0606(6) Uani 1 d . . . H28A H 0.0757 -0.1466 0.2205 0.073 Uiso 1 calc R . . O29 O -0.00674(8) -0.25996(15) -0.03611(11) 0.0793(6) Uani 1 d . . . C30 C -0.05652(12) -0.2043(2) -0.06195(14) 0.0650(7) Uani 1 d . . . C31 C -0.05388(15) -0.1135(2) -0.07946(16) 0.0795(9) Uani 1 d . . . H31A H -0.0175 -0.0866 -0.0702 0.095 Uiso 1 calc R . . C32 C -0.10505(16) -0.0621(2) -0.11073(17) 0.0852(10) Uani 1 d . . . H32A H -0.1033 -0.0005 -0.1224 0.102 Uiso 1 calc R . . C33 C -0.15866(14) -0.1016(2) -0.12461(15) 0.0786(9) Uani 1 d . . . H33A H -0.1932 -0.0668 -0.1462 0.094 Uiso 1 calc R . . C34 C -0.16167(13) -0.1923(2) -0.10692(14) 0.0704(8) Uani 1 d . . . H34A H -0.1982 -0.2188 -0.1163 0.084 Uiso 1 calc R . . C35 C -0.11064(12) -0.24386(18) -0.07526(13) 0.0618(7) Uani 1 d . . . O36 O -0.11503(9) -0.33691(13) -0.06456(10) 0.0786(6) Uani 1 d . . . C37 C -0.08598(12) -0.37320(18) 0.01491(14) 0.0620(7) Uani 1 d . . . C38 C -0.08270(12) -0.32841(18) 0.08576(14) 0.0635(7) Uani 1 d . . . H38A H -0.0995 -0.2707 0.0820 0.076 Uiso 1 calc R . . C39 C -0.05409(11) -0.37054(18) 0.16258(14) 0.0605(6) Uani 1 d . . . H39A H -0.0518 -0.3406 0.2106 0.073 Uiso 1 calc R . . C40 C -0.02882(11) -0.45614(17) 0.16949(13) 0.0578(6) Uani 1 d . . . C41 C -0.03402(13) -0.50020(19) 0.09675(16) 0.0709(8) Uani 1 d . . . H41A H -0.0184 -0.5586 0.0999 0.085 Uiso 1 calc R . . C42 C -0.06207(14) -0.45879(19) 0.01956(16) 0.0733(8) Uani 1 d . . . H42A H -0.0647 -0.4886 -0.0287 0.088 Uiso 1 calc R . . C43 C 0.0000 -0.5068(3) 0.2500 0.0649(9) Uani 1 d S . . O43 O 0.0000 -0.5900(2) 0.2500 0.1028(12) Uani 1 d S . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 C1 0.046(2) 0.065(2) 0.090(3) 0.000 0.0213(18) 0.000 O1 0.0600(18) 0.0655(18) 0.145(3) 0.000 0.0116(18) 0.000 C2 0.0455(14) 0.0633(15) 0.0737(16) 0.0059(12) 0.0133(12) 0.0017(11) C3 0.0598(16) 0.0713(17) 0.0636(15) 0.0102(13) 0.0064(12) -0.0020(13) C4 0.0684(18) 0.0629(16) 0.0690(16) 0.0099(13) 0.0026(13) -0.0046(14) C5 0.0534(15) 0.0674(16) 0.0617(14) 0.0060(12) 0.0072(12) 0.0051(12) C6 0.0511(15) 0.0825(19) 0.0758(17) 0.0265(14) 0.0097(13) 0.0074(13) C7 0.0454(14) 0.0717(17) 0.095(2) 0.0228(15) 0.0151(13) 0.0024(13) O8 0.0621(12) 0.0708(12) 0.0710(11) 0.0019(9) -0.0058(9) 0.0079(9) C9 0.0531(15) 0.0711(16) 0.0511(13) 0.0037(11) 0.0040(11) 0.0040(12) C10 0.082(2) 0.100(2) 0.0629(16) -0.0089(15) 0.0258(15) 0.0118(18) C11 0.084(2) 0.114(3) 0.0425(13) -0.0077(14) 0.0137(13) 0.0000(19) C12 0.0678(18) 0.090(2) 0.0464(13) 0.0043(13) -0.0003(12) 0.0011(16) C13 0.0612(16) 0.0707(16) 0.0532(14) -0.0014(12) 0.0076(12) 0.0057(13) C14 0.0597(15) 0.0645(14) 0.0375(11) -0.0031(10) 0.0053(10) -0.0007(12) O15 0.0871(13) 0.0638(11) 0.0422(8) -0.0042(7) 0.0145(8) -0.0076(9) C16 0.0578(14) 0.0582(14) 0.0406(11) -0.0003(10) 0.0068(10) 0.0008(11) C17 0.0655(16) 0.0708(16) 0.0379(11) 0.0059(11) 0.0034(10) -0.0003(13) C18 0.0590(15) 0.0624(15) 0.0476(12) 0.0130(11) 0.0044(11) 0.0035(12) C19 0.0476(14) 0.0591(14) 0.0472(12) 0.0046(10) 0.0016(10) 0.0018(11) C20 0.0644(16) 0.0639(15) 0.0388(11) 0.0023(10) 0.0064(10) -0.0027(12) C21 0.0736(17) 0.0612(14) 0.0414(11) 0.0042(10) 0.0113(11) -0.0040(13) C22 0.0504(14) 0.0613(15) 0.0582(14) 0.0051(11) 0.0046(11) 0.0005(12) O22 0.0785(14) 0.0596(11) 0.0802(12) 0.0097(9) -0.0059(10) 0.0036(10) C23 0.0467(14) 0.0544(13) 0.0563(13) -0.0011(11) 0.0049(10) -0.0053(11) C24 0.0562(15) 0.0578(15) 0.0738(16) -0.0092(12) 0.0105(12) -0.0012(12) C25 0.0581(16) 0.0665(16) 0.0680(15) -0.0203(12) 0.0114(12) -0.0048(13) C26 0.0503(14) 0.0732(16) 0.0513(13) -0.0090(12) 0.0065(11) -0.0079(12) C27 0.0500(14) 0.0751(17) 0.0517(13) -0.0053(12) 0.0068(11) 0.0033(12) C28 0.0547(14) 0.0650(15) 0.0488(12) -0.0054(11) 0.0076(10) 0.0000(12) O29 0.0608(12) 0.1046(15) 0.0515(9) -0.0202(9) 0.0014(8) 0.0012(11) C30 0.0602(16) 0.0805(18) 0.0379(11) -0.0028(11) 0.0031(10) -0.0021(14) C31 0.079(2) 0.094(2) 0.0563(15) 0.0033(14) 0.0180(14) -0.0192(17) C32 0.101(3) 0.082(2) 0.0552(15) 0.0169(14) 0.0133(16) -0.0065(19) C33 0.077(2) 0.091(2) 0.0463(13) 0.0072(13) 0.0030(13) 0.0103(17) C34 0.0603(16) 0.096(2) 0.0411(12) -0.0011(12) 0.0062(11) -0.0043(15) C35 0.0669(17) 0.0717(16) 0.0317(10) -0.0029(10) 0.0045(10) -0.0125(13) O36 0.0918(15) 0.0730(12) 0.0421(9) -0.0035(8) -0.0020(9) -0.0174(10) C37 0.0603(15) 0.0667(15) 0.0435(12) -0.0035(11) 0.0054(10) -0.0093(12) C38 0.0647(16) 0.0628(15) 0.0501(13) -0.0028(11) 0.0104(11) 0.0034(12) C39 0.0602(15) 0.0662(15) 0.0472(12) -0.0055(11) 0.0140(11) 0.0044(12) C40 0.0560(14) 0.0616(15) 0.0467(13) -0.0040(10) 0.0115(10) -0.0036(11) C41 0.0805(19) 0.0628(16) 0.0582(14) -0.0093(12) 0.0170(13) 0.0010(14) C42 0.092(2) 0.0685(17) 0.0494(13) -0.0137(12) 0.0188(13) -0.0029(15) C43 0.067(2) 0.057(2) 0.060(2) 0.000 0.0149(17) 0.000 O43 0.146(3) 0.0597(18) 0.0718(18) 0.000 0.0129(18) 0.000 _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag C1 O1 1.226(5) . ? C1 C2 1.487(3) . ? C1 C2 1.487(3) 6_556 ? C2 C7 1.385(4) . ? C2 C3 1.389(4) . ? C3 C4 1.386(4) . ? C4 C5 1.372(3) . ? C5 C6 1.369(4) . ? C5 O8 1.380(3) . ? C6 C7 1.375(4) . ? O8 C9 1.388(3) . ? C9 C14 1.378(4) . ? C9 C10 1.382(4) . ? C10 C11 1.380(4) . ? C11 C12 1.353(4) . ? C12 C13 1.382(4) . ? C13 C14 1.372(3) . ? C14 O15 1.392(3) . ? O15 C16 1.380(3) . ? C16 C17 1.376(3) . ? C16 C21 1.386(3) . ? C17 C18 1.376(3) . ? C18 C19 1.390(3) . ? C19 C20 1.390(3) . ? C19 C22 1.482(3) . ? C20 C21 1.372(3) . ? C22 O22 1.218(3) . ? C22 C23 1.489(3) . ? C23 C28 1.383(3) . ? C23 C24 1.384(4) . ? C24 C25 1.380(4) . ? C25 C26 1.377(4) . ? C26 C27 1.374(4) . ? C26 O29 1.384(3) . ? C27 C28 1.383(3) . ? O29 C30 1.386(3) . ? C30 C31 1.371(4) . ? C30 C35 1.384(4) . ? C31 C32 1.375(5) . ? C32 C33 1.370(4) . ? C33 C34 1.371(4) . ? C34 C35 1.374(4) . ? C35 O36 1.385(3) . ? O36 C37 1.386(3) . ? C37 C42 1.372(4) . ? C37 C38 1.377(4) . ? C38 C39 1.384(3) . ? C39 C40 1.382(3) . ? C40 C41 1.387(3) . ? C40 C43 1.492(3) . ? C41 C42 1.383(4) . ? C43 O43 1.219(4) . ? C43 C40 1.492(3) 6_556 ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag O1 C1 C2 118.78(17) . . ? O1 C1 C2 118.78(17) . 6_556 ? C2 C1 C2 122.4(3) . 6_556 ? C7 C2 C3 117.6(2) . . ? C7 C2 C1 118.2(3) . . ? C3 C2 C1 124.1(2) . . ? C4 C3 C2 120.6(2) . . ? C5 C4 C3 120.0(3) . . ? C6 C5 C4 120.3(2) . . ? C6 C5 O8 123.2(2) . . ? C4 C5 O8 116.5(2) . . ? C5 C6 C7 119.4(2) . . ? C6 C7 C2 122.0(3) . . ? C5 O8 C9 119.6(2) . . ? C14 C9 C10 119.1(2) . . ? C14 C9 O8 122.3(2) . . ? C10 C9 O8 118.4(3) . . ? C11 C10 C9 119.9(3) . . ? C12 C11 C10 120.7(3) . . ? C11 C12 C13 120.0(3) . . ? C14 C13 C12 119.9(3) . . ? C13 C14 C9 120.5(2) . . ? C13 C14 O15 121.7(2) . . ? C9 C14 O15 117.6(2) . . ? C16 O15 C14 119.49(19) . . ? C17 C16 O15 125.0(2) . . ? C17 C16 C21 121.0(2) . . ? O15 C16 C21 114.0(2) . . ? C16 C17 C18 118.9(2) . . ? C17 C18 C19 121.6(2) . . ? C20 C19 C18 117.9(2) . . ? C20 C19 C22 122.3(2) . . ? C18 C19 C22 119.6(2) . . ? C21 C20 C19 121.4(2) . . ? C20 C21 C16 119.1(2) . . ? O22 C22 C19 120.9(2) . . ? O22 C22 C23 120.4(2) . . ? C19 C22 C23 118.7(2) . . ? C28 C23 C24 119.0(2) . . ? C28 C23 C22 121.1(2) . . ? C24 C23 C22 119.8(2) . . ? C25 C24 C23 120.6(3) . . ? C26 C25 C24 119.2(2) . . ? C27 C26 C25 121.2(2) . . ? C27 C26 O29 124.0(2) . . ? C25 C26 O29 114.7(2) . . ? C26 C27 C28 119.0(3) . . ? C27 C28 C23 120.8(2) . . ? C26 O29 C30 118.9(2) . . ? C31 C30 C35 119.9(3) . . ? C31 C30 O29 121.8(3) . . ? C35 C30 O29 118.2(3) . . ? C30 C31 C32 120.0(3) . . ? C33 C32 C31 120.0(3) . . ? C32 C33 C34 120.4(3) . . ? C33 C34 C35 119.8(3) . . ? C34 C35 C30 119.9(3) . . ? C34 C35 O36 119.1(3) . . ? C30 C35 O36 120.8(3) . . ? C35 O36 C37 118.42(18) . . ? C42 C37 C38 121.0(2) . . ? C42 C37 O36 116.3(2) . . ? C38 C37 O36 122.7(2) . . ? C37 C38 C39 119.0(2) . . ? C40 C39 C38 121.4(2) . . ? C39 C40 C41 118.1(2) . . ? C39 C40 C43 123.8(2) . . ? C41 C40 C43 117.9(2) . . ? C42 C41 C40 121.2(3) . . ? C37 C42 C41 119.3(2) . . ? O43 C43 C40 119.77(15) . . ? O43 C43 C40 119.77(15) . 6_556 ? C40 C43 C40 120.5(3) . 6_556 ? _diffrn_measured_fraction_theta_max 0.468 _diffrn_reflns_theta_full 61.96 _diffrn_measured_fraction_theta_full 0.468 _refine_diff_density_max 0.182 _refine_diff_density_min -0.135 _refine_diff_density_rms 0.033