18F‑Positron
Emitting/Trimethine
Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management
Posted on 2018-04-20 - 18:48
[18/19F]-4, an anionic GCPII/PSMA inhibitor
for image-guided intervention in prostate cancer, is described. [19F]-4 is radiolabeled with a radiochemical yield
that is ≥27% and a molar activity of 190 ± 50 mCi/μmol
in a <1 h, one-step, aqueous isotopic exchange reaction. [19F]-4 allows PSMA expression to be imaged by
fluorescence (FL) and [18F]-PET. PC3-PIP (PSMA-positive,
EC50 = 6.74 ± 1.33 nM) cancers are specifically delineated
in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative)
cells. Colocalization of [18/19F]-4 PET, fluorescence,
scintillated biodistribution, and PSMA expression are observed.
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Kommidi, Harikrishna; Guo, Hua; Nurili, Fuad; Vedvyas, Yogindra; Jin, Moonsoo M.; McClure, Timothy D.; et al. (2018). 18F‑Positron
Emitting/Trimethine
Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management. ACS Publications. Collection. https://doi.org/10.1021/acs.jmedchem.8b00240
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AUTHORS (11)
HK
Harikrishna Kommidi
HG
Hua Guo
FN
Fuad Nurili
YV
Yogindra Vedvyas
MJ
Moonsoo M. Jin
TM
Timothy D. McClure
BE
Behfar Ehdaie
HS
Haluk B. Sayman
OA
Oguz Akin
OA
Omer Aras
RT
Richard Ting