N-Acyl Derivatives of Arginine and
Tryptophan Isolated from Environmental
DNA Expressed in Escherichia coli

Clardy, Jon

N-Acyl Derivatives of Arginine and Tryptophan Isolated from Environmental DNA Expressed in Escherichia coli

Posted on 2005-08-18 - 00:00

Heterologous expression of microbial DNA extracted directly from environmental samples (environmental DNA, eDNA) in easily cultured hosts can provide access to natural products produced by previously uncultured bacteria. This report describes the characterization of antibacterially active long-chain N-acyl derivatives of tryptophan and arginine that are produced by eDNA clones hosted in Escherichia coli. The sequencing and subcloning of the proposed N-acyl amino acid synthases (NASs) for each family of natural products are also described.

CITE THIS COLLECTION

Brady, Sean F.; Clardy, Jon (2016). N-Acyl Derivatives of Arginine and Tryptophan Isolated from Environmental DNA Expressed in Escherichia coli. ACS Publications. Collection. https://doi.org/10.1021/ol0509585

https://doi.org/10.1021/ol0509585

or

Select your citation style and then place your mouse over the citation text to select it.