Zinc(II)-Tetradentate-Coordinated Probe with Aggregation-Induced
Emission Characteristics for Selective Imaging and Photoinactivation
of Bacteria
Posted on 2017-02-28 - 00:00
The
emergence of drug-resistant bacterial pathogens highlights an urgent need for new
therapeutic options. Photodynamic therapy (PDT) has emerged as a potential
alternative to antibiotics to kill bacteria, which has been used in
clinical settings. PDT employs photosensitizers (PSs), light, and
oxygen to kill bacteria by generating highly reactive oxygen species
(ROS). PDT can target both
external and internal structures of bacteria, which does not really
require the PSs to enter bacteria. Therefore, bacteria can hardly
develop resistance to PDT. However, most of the PSs reported so far
are hydrophobic and tend to form aggregates when they interact with
bacteria. The aggregation could cause fluorescence quenching and reduce
ROS generation, which generally compromises the effects of both imaging
and therapy. In this contribution, we report on a Zn(II)-tetradentate-coordinated
red-emissive probe with aggregation-induced emission characterization.
The probe could selectively image bacteria over mammalian cells. Moreover,
the probe shows potent phototoxicity to both Gram-negative bacteria
(Escherichia coli) and Gram-positive
bacteria (Bacillus subtilis).
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Feng, Guangxue; Zhang, Chong-Jing; Lu, Xianmao; Liu, Bin (2017). Zinc(II)-Tetradentate-Coordinated Probe with Aggregation-Induced
Emission Characteristics for Selective Imaging and Photoinactivation
of Bacteria. ACS Publications. Collection. https://doi.org/10.1021/acsomega.6b00564
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