Water-Soluble Cuprizone Derivative: Synthesis, Characterization,
and in Vitro Studies

Clarner, Tim

Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies

Posted on 2019-01-18 - 18:39

The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone.

CITE THIS COLLECTION

DataCite

3 Biotech

3D Printing in Medicine

3D Research

3D-Printed Materials and Systems

4OR

AAPG Bulletin

AAPS Open

AAPS PharmSciTech

Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg

ABI Technik (German)

Academic Medicine

Academic Pediatrics

Academic Psychiatry

Academic Questions

Academy of Management Discoveries

Academy of Management Journal

Academy of Management Learning and Education

Academy of Management Perspectives

Academy of Management Proceedings

Academy of Management Review

Fries, Martin; Mertens, Meike; Teske, Nico; Kipp, Markus; Beyer, Cordian; Willms, Thomas; et al. (2019). Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies. ACS Publications. Collection. https://doi.org/10.1021/acsomega.8b02523

https://doi.org/10.1021/acsomega.8b02523

or

Select your citation style and then place your mouse over the citation text to select it.