Walrobsins A and B, Two Anti-inflammatory Limonoids
from Root Barks of Walsura robusta
Posted on 2017-08-18 - 18:48
Walrobsins
A (1) and B (2), two limonoids
featuring an unprecedented 5-oxatricyclo[5.4.11,4]hendecane ring system, were isolated from the root barks of Walsura robusta. Their structures, including their absolute
configurations, were determined by analyses of HR-ESIMS, 1D/2D NMR,
and X-ray crystallography. Compounds 1 and 2 possessed a stable hemiketal structure formed between the OH-11
and 3-carbonyl group in the hexatomic oxoheterocyclic ring. Compound 1 showed significant anti-inflammatory activity with an IC50 value of 7.8 μM and inhibited the expression of iNOS
and IL-1β in a dose-dependent manner.
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An, Fa-Liang; Sun, Dong-Mei; Li, Rui-Jun; Zhou, Miao-Miao; Yang, Ming-Hua; Yin, Yong; et al. (2017). Walrobsins A and B, Two Anti-inflammatory Limonoids
from Root Barks of Walsura robusta. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b02173
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AUTHORS (8)
FA
Fa-Liang An
DS
Dong-Mei Sun
RL
Rui-Jun Li
MZ
Miao-Miao Zhou
MY
Ming-Hua Yang
YY
Yong Yin
LK
Ling-Yi Kong
JL
Jun Luo
KEYWORDS
hemiketal structureIL -1βconfigurationanti-inflammatory activitydose-dependent mannerWalsura robusta WalrobsinsWalsura robustalimonoidIC 50 valuehendecanehexatomic oxoheterocyclic ring3- carbonyl group7.8 μ MHR-ESIMSX-ray crystallographyCompounds 1analysesRoot BarksNMRoxatriexpressionCompound 15-Anti-inflammatory LimonoidsOH -11iNOS