Ultraviolet
Radiant Energy-Dependent Functionalization
Regulates Cellular Behavior on Titanium Dioxide Nanodots
Posted on 2020-06-15 - 19:09
Titanium
dioxide (TiO2) photofunctionalization has been
demonstrated as an effective surface modification method for the osseointegration
of implants. However, the insufficient understanding of the mechanism
underlying photofunctionalization limits its clinical applications.
Here, we report an ultraviolet (UV) radiant energy-dependent functionalization
on TiO2 nanodots (TN) surfaces. We found the cell adhesion,
proliferation, and osteogenic differentiation gradually increased
with the accumulation of UV radiant energy (URE). The optimal functionalizing
treatment energy was found to be 2000 mJ/cm2, which could
regulate cell-specific behaviors on TN surfaces. The enhanced cell
behaviors were regulated by the adsorption and functional site exposure
of the extracellular matrix (ECM) proteins, which were the result
of the surface physicochemical changes induced by the URE. The correlation
between the URE and the reconstruction of surface hydroxyl groups
was considered as an alternative mechanism of this energy-dependent
functionalization. We also demonstrated the synergistic effects of
FAK-RHOA and ERK1/2 signaling pathways on mediating the URE-dependent
cell behaviors. Overall, this study provides a novel insight into
the mechanisms of photofunctionalization, guiding the design of implants
and the clinical practice of photofunctionalization.
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Liu, Chao; Sun, Mouyuan; Wang, Yu; Zhu, Tianer; Ye, Guanchen; You, Dongqi; et al. (2020). Ultraviolet
Radiant Energy-Dependent Functionalization
Regulates Cellular Behavior on Titanium Dioxide Nanodots. ACS Publications. Collection. https://doi.org/10.1021/acsami.0c07761
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AUTHORS (13)
CL
Chao Liu
MS
Mouyuan Sun
YW
Yu Wang
TZ
Tianer Zhu
GY
Guanchen Ye
DY
Dongqi You
LD
Lingqing Dong
WZ
Wenquan Zhao
KC
Kui Cheng
WW
Wenjian Weng
YZ
Yu Shrike Zhang
MY
Mengfei Yu
HW
Huiming Wang
KEYWORDS
FAK-RHOAphotofunctionalizationfunctionalizing treatment energyTiO 2 nanodotsURE-dependent cell behaviorsUVTitanium Dioxide Nanodots Titanium dioxideECMsurface modification methodEnergy-Dependent Functionalization Regulates Cellular Behaviorsurface physicochemical changesenergy-dependent functionalizationERKmechanismTNimplantsurface hydroxyl groups