Ultrasound-Driven
Biomimetic Nanosystem Suppresses
Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy,
and Indoleamine 2,3-Dioxygenase Inhibition
Posted on 2020-07-16 - 15:20
The
rational design of nanoplatforms to bypass reticuloendothelial
system (RES) clearance, enhance spatiotemporal controllability, and
boost host immune responses to achieve synergized tumor-targeted therapeutic
purpose is highly desired. Herein, a biomimetic nanosystem is developed
for tumor-targeted in situ delivery of singlet oxygen
(1O2) and carbon monoxide (CO) in response to
exogenous stimulus ultrasound (US) and endogenous stimulus hydrogen
peroxide (H2O2) in tumor microenvironment, respectively.
Taking advantages of tumor homing and RES evasion abilities of the
macrophage membrane coating, our designed nanosystem shows excellent
accumulation at the tumor site and effective suppression of tumor
growth through US/H2O2-generated 1O2 and CO to induce cell apoptosis and mitochondrial dysfunction.
Furthermore, our nanosystem can induce significant tumor immunogenic
death by 1O2/CO therapy, then can achieve effective
immune responses and long-term immune memory through the combination
of indoleamin 2,3-dioxygenase (IDO) signal blocking to effectively
against tumor rechallenge and prevent lung metastasis. Taken together,
the here-presented therapeutic strategy based on sonodynamic/CO therapy
and IDO signaling inhibition might provide a promising perspective
for synergistically treating cancer in future clinical translations.
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Zhang, Da; Lin, Ziguo; Zheng, Youshi; Song, Jibin; Li, Juan; Zeng, Yongyi; et al. (2020). Ultrasound-Driven
Biomimetic Nanosystem Suppresses
Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy,
and Indoleamine 2,3-Dioxygenase Inhibition. ACS Publications. Collection. https://doi.org/10.1021/acsnano.0c03833
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AUTHORS (7)
DZ
Da Zhang
ZL
Ziguo Lin
YZ
Youshi Zheng
JS
Jibin Song
JL
Juan Li
YZ
Yongyi Zeng
XL
Xiaolong Liu
KEYWORDS
tumor immunogenic deathexogenous stimulus ultrasoundUltrasound-Driven Biomimetic Nanosy...carbon monoxideIDOCO Therapytumor microenvironmenttumor rechallengelung metastasistumor sitespatiotemporal controllabilitytumor growthstimulus hydrogen peroxide1 O 2macrophage membrane coatingsinglet oxygenH 2 O 2synergized tumor-targetedreticuloendothelial systemRES evasion abilitiescell apoptosisbiomimetic nanosystemresponseSonodynamic Therapymitochondrial dysfunction