Ultrasensitive Detection of Human Chorionic Gonadotropin
Using Frequency Locked Microtoroid Optical Resonators
Version 2 2019-08-26, 15:35
Version 1 2019-08-23, 19:16
Posted on 2019-08-26 - 15:35
Clean
sport competition is of significant concern to many governments
and sporting organizations. Highly sensitive and rapid sensors are
needed to improve the detection of performance enhancing drugs in
sports as athletes take diuretics to dilute the concentration of drugs
in their urine and microdose under the detectable limits of current
sensors. Here we demonstrate, using frequency locked microtoroid optical
resonators, a 3 orders of magnitude improvement in detection limit
over the current gold standard, mass spectrometry, for the common
performance enhancing drug, human chorionic gonadotropin (hCG). hCG,
also known as the pregnancy hormone, was detected both in simulated
urine and in the urine of pregnant donors at a concentration of 1
and 3 femtomolar, respectively. We anticipate that the sensitivity
provided by frequency locked optical microcavities can enable a new
standard in antidoping research.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Ozgur, Erol; Roberts, Kara Ellen; Ozgur, Ekin Ozge; Gin, Adley Nathanael; Bankhead, Jaden Robert; Wang, Zhikun; et al. (2019). Ultrasensitive Detection of Human Chorionic Gonadotropin
Using Frequency Locked Microtoroid Optical Resonators. ACS Publications. Collection. https://doi.org/10.1021/acs.analchem.9b02630
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (7)
EO
Erol Ozgur
KR
Kara Ellen Roberts
EO
Ekin Ozge Ozgur
AG
Adley Nathanael Gin
JB
Jaden Robert Bankhead
ZW
Zhikun Wang
JS
Judith Su