Triphenylquinoline (TPQ)-Based Dual-State Emissive
Probe for Cell Imaging in Multicellular Tumor Spheroids
Posted on 2019-08-01 - 19:44
Insufficient
intratumoral penetration and limited stroma distribution
of the imaging probes or theranostics can lead to a poor-quality diagnosis
or therapeutic resistance. Multicellular tumor spheroids can recapitulate
the physiological environment of tumor tissues with the extracellular
matrix and is thus a better in vitro tumor model to evaluate the imaging
performance and barrier penetration capability of advanced cancer
imaging probes. In this Article, we designed and synthesized a series
of quinoline-based fluorophores with strong emissions in both solution
and solid states. The quinoline core can be constructed via a one-pot
iron-catalysis reaction. Optical properties and single crystal structures
of these quinoline derivatives were tuned by varying the substitutes
at the 6-position of the quinoline core. The twisted intramolecular
charge transfer effect can enhance the fluorescent efficiency, resulting
in the high quantum yield of TPQ-TPA in both solution
(70%) and solid (48%) states (TPQ, triphenylquinoline; TPA, triphenylamine).
In addition, TPQ-TPA exhibited a good biocompatibility
and can deeply penetrate into 3D tumor spheroids within 12 h. The
results indicated that quinoline can be a new fluorescent scaffold,
and the employment of quinoline-based probes will provide a new platform
for biological applications.
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Dai, Wenbo; Liu, Pai; Guo, Shuai; Liu, Zhiqi; Wang, Mengni; Shi, Jianbing; et al. (2019). Triphenylquinoline (TPQ)-Based Dual-State Emissive
Probe for Cell Imaging in Multicellular Tumor Spheroids. ACS Publications. Collection. https://doi.org/10.1021/acsabm.9b00596
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AUTHORS (10)
WD
Wenbo Dai
PL
Pai Liu
SG
Shuai Guo
ZL
Zhiqi Liu
MW
Mengni Wang
JS
Jianbing Shi
BT
Bin Tong
TL
Tianqing Liu
ZC
Zhengxu Cai
YD
Yuping Dong