Toward a Synthetic
Yeast Endosymbiont with a Minimal Genome
Posted on 2019-08-24 - 13:29
Based on the endosymbiotic theory,
one of the key events that occurred
during mitochondrial evolution was an extensive loss of nonessential
genes from the protomitochondrial endosymbiont genome and transfer
of some of the essential endosymbiont genes to the host nucleus. We
have developed an approach to recapitulate various aspects of endosymbiont
genome minimization using a synthetic system consisting of Escherichia coli endosymbionts within host yeast
cells. As a first step, we identified a number of E.
coli auxotrophs of central metabolites that can form
viable endosymbionts within yeast cells. These studies provide a platform
to identify nonessential biosynthetic pathways that can be deleted
in the E. coli endosymbionts to investigate
the evolutionary adaptations in the host and endosymbiont during the
evolution of mitochondria.
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Mehta, Angad
P.; Ko, Yeonjin; Supekova, Lubica; Pestonjamasp, Kersi; Li, Jack; Schultz, Peter G. (2019). Toward a Synthetic
Yeast Endosymbiont with a Minimal Genome. ACS Publications. Collection. https://doi.org/10.1021/jacs.9b08290
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AUTHORS (6)
AM
Angad
P. Mehta
YK
Yeonjin Ko
LS
Lubica Supekova
KP
Kersi Pestonjamasp
JL
Jack Li
PS
Peter G. Schultz