Total Synthesis of Spirotryprostatin B
via Diastereoselective Prenylation

Stiles, Dylan T.

Total Synthesis of Spirotryprostatin B via Diastereoselective Prenylation

Posted on 2007-07-19 - 00:00

Spirotryprostatin B was synthesized in eight steps, utilizing an efficient palladium-catalyzed prenylation reaction to construct the quaternary C3 stereocenter. The decarboxylation−alkylation of a series of substituted β-keto esters is described, demonstrating the broad scope of this class of pronucleophiles and allylating agents.

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Trost, Barry M.; Stiles, Dylan T. (2016). Total Synthesis of Spirotryprostatin B via Diastereoselective Prenylation. ACS Publications. Collection. https://doi.org/10.1021/ol070971k

https://doi.org/10.1021/ol070971k

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