Thermosensitive bFGF-Modified Hydrogel with Dental
Pulp Stem Cells on Neuroinflammation of Spinal Cord Injury
Posted on 2020-06-25 - 15:34
Acute
spinal cord injury (SCI) induces severe neuroinflammation,
which increases intermediary filaments and neurodegeneration. Previous
studies have shown that a basic fibroblast growth factor (bFGF) and
dental pulp stem cells (DPSCs) contribute to a protective effect on
injured neuronal cells, but the mechanism of SCI repair is still unclear.
In this study, in situ heparin (HeP) hydrogel injection containing
bFGF and DPSCs (HeP-bFGF-DPSCs), as well as in vitro studies of bFGF
and DPSCs, proved an effective control over inflammation. The in vivo
application of HeP-bFGF-DPSCs regulated inflammatory reactions and
accelerated the nerve regeneration through microtubule stabilization
and tissue vasculature. Our mechanistic investigation also showed
that bFGF-DPSCs treatment inhibited microglia/macrophage proliferation
and activation. Furthermore, HeP-bFGF-DPSCs prevented microglia/macrophage
activation and reduced proinflammatory cytokine release. In this paper,
we discovered that bFGF and DPSCs worked together to attenuate tissue
inflammation of the injured spinal cord, resulting in a superior nerve
repair. Our results indicated that a thermosensitive hydrogel delivering
bFGF and DPSCs could serve as a promising treatment option for spinal
cord injuries.
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Albashari, Abdullkhaleg; He, Yan; Zhang, Yanni; Ali, Jihea; Lin, Feiou; Zheng, Zengming; et al. (2020). Thermosensitive bFGF-Modified Hydrogel with Dental
Pulp Stem Cells on Neuroinflammation of Spinal Cord Injury. ACS Publications. Collection. https://doi.org/10.1021/acsomega.0c01379