Thermosensitive Polysaccharide Hydrogel As a Versatile
Platform for Prolonged Salmon Calcitonin Release and Calcium Regulation
Posted on 2020-06-16 - 11:36
The common pathological characteristic
of osteoporosis and hypercalcemia
is the disorder of calcium homeostasis. Currently, salmon calcitonin
(sCT), a clinical regenerative medicine, is an attractive chioice
to regulate calcium metabolism for alleviation of osteoporosis and
hypercalcemia. Unfortunately, serum sCT is quickly cleared in vivo,
leading to its short half-life. Here, we designed a versatile hydrogel,
based on salmon calcitonin-oxidized calcium alginate (sCT-OCA) conjugate
and hydroxypropyl chitin (HPCH). The release profile showed that sCT
could be released from HPCH hydrogels loaded with sCT-OCA conjugate
(sCT-OCA-HPCH) for at least 28 days with conformation stability. The
cellular test demonstrated that the biocompatible sCT-OCA-HPCH, compared
with sCT formulation, had capacity in up-regulating alkaline phosphatase
activity (∼63% increase) and promoting calcium to deposit into
extracellular matrix (∼42% increase). These results indicated
that thermosensitive sCT-OCA-HPCH hydrogel herein is a versatile platform
for many applications such as calcium metabolism regulation, osteoporosis
treatment, and hypercalcemia therapy.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Yu, Peng; Liu, Yanpeng; Jin, Ruitao; Zhang, Pan; Ding, Chunmei; Jiang, Xulin; et al. (2020). Thermosensitive Polysaccharide Hydrogel As a Versatile
Platform for Prolonged Salmon Calcitonin Release and Calcium Regulation. ACS Publications. Collection. https://doi.org/10.1021/acsbiomaterials.0c00591
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (10)
PY
Peng Yu
YL
Yanpeng Liu
RJ
Ruitao Jin
PZ
Pan Zhang
CD
Chunmei Ding
XJ
Xulin Jiang
JX
Jiaqi Xing
BB
Bo Bi
JX
Jing Xie
JL
Jianshu Li
KEYWORDS
Versatile Platformsalmon calcitoninsalmon calcitonin-oxidized calcium alginatethermosensitive sCT-OCA-HPCH hydrogelsCT formulationhypercalcemia therapyrelease profileCalcium RegulationHPCH hydrogelsSalmon Calcitonin Releasebiocompatible sCT-OCA-HPCHconformation stabilityosteoporosis treatmentserum sCTThermosensitive Polysaccharide Hydrogelregenerative medicinesCT-OCA conjugatecalcium metabolismcalcium homeostasishydroxypropyl chitincalcium metabolism regulation28 days