The First Conjugate Addition Reaction of Terminal Alkynes Catalytic in
Copper: Conjugate Addition of Alkynes in Water
Posted on 2003-04-23 - 00:00
We document that alkynyl copper reagents generated under aqueous conditions from terminal acetylenes, catalytic Cu(OAc)2, and sodium ascorbate undergo additions to Meldrum's acid-derived Michael acceptors at room temperature (Scheme ). The additions are not only novel, but also constitute the first example of the conjugate addition reaction of an acetylide catalytic in copper.
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Knöpfel, Thomas F.; Carreira, Erick M. (2016). The First Conjugate Addition Reaction of Terminal Alkynes Catalytic in
Copper: Conjugate Addition of Alkynes in Water. ACS Publications. Collection. https://doi.org/10.1021/ja035311z
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