TFA-Mediated DMSO-Participant Sequential Oxidation/1,3-Dipolar Cycloaddition Cascade of Pyridinium Ylides for the Assembly of Indolizines

Published on 2019-02-12T15:12:45Z (GMT) by
A trifluoroacetic acid (TFA)-mediated cascade oxidation/1,3-dipolar cycloaddition reaction of stabilized pyridinium salts with dimethyl sulfoxide (DMSO) has been developed in the presence of K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> and trimethylethylenediamine (TMEDA). In this transition-metal-free reaction, DMSO acts as a one-carbon source, thus providing a convenient method for the efficient and direct synthesis of various indolizine derivatives.

Cite this collection

Shu, Wen-Ming; He, Jian-Xin; Zhang, Xun-Fang; Wang, Shuai; Wu, An-Xin (2019): TFA-Mediated DMSO-Participant

Sequential Oxidation/1,3-Dipolar

Cycloaddition Cascade of Pyridinium Ylides for the Assembly of Indolizines. ACS Publications. Collection.