Synthesis of 18F‑Labeled Aryl Fluorosulfates
via Nucleophilic Radiofluorination
Posted on 2020-06-26 - 14:34
Sulfuryl fluoride gas is a key reagent
for SO2F transfer.
However, conventional SO2F transfer reactions have limited 18F-radiochemistry translation, due to the inaccessibility
of gaseous [18F]SO2F2. Herein, we
report the first SO2F2-free synthesis of aryl
[18F]fluorosulfates from both phenolic and isolated aryl
imidazylate precursors with cyclotron-produced 18F–. The radiochemical yields ranged from moderate to
good with excellent functional group tolerance. The reliability of
our approach was validated by the automated radiosynthesis of 4-acetamidophenyl
[18F]fluorosulfate.
CITE THIS COLLECTION
DataCiteDataCite
3 Biotech3 Biotech
3D Printing in Medicine3D Printing in Medicine
3D Research3D Research
3D-Printed Materials and Systems3D-Printed Materials and Systems
4OR4OR
AAPG BulletinAAPG Bulletin
AAPS OpenAAPS Open
AAPS PharmSciTechAAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität HamburgAbhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)ABI Technik (German)
Academic MedicineAcademic Medicine
Academic PediatricsAcademic Pediatrics
Academic PsychiatryAcademic Psychiatry
Academic QuestionsAcademic Questions
Academy of Management DiscoveriesAcademy of Management Discoveries
Academy of Management JournalAcademy of Management Journal
Academy of Management Learning and EducationAcademy of Management Learning and Education
Academy of Management PerspectivesAcademy of Management Perspectives
Academy of Management ProceedingsAcademy of Management Proceedings
Academy of Management ReviewAcademy of Management Review
Kwon, Young-Do; Jeon, Min Ho; Park, Nam Kyu; Seo, Jeong Kon; Son, Jeongmin; Ryu, Young Hoon; et al. (2020). Synthesis of 18F‑Labeled Aryl Fluorosulfates
via Nucleophilic Radiofluorination. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c01868