Synthesis of Symmetric
1,4-Diamino-2-Butynes via a Cu(I)-Catalyzed One-Pot A3-Coupling/Decarboxylative
Coupling of a Propiolic Acid, an Aldehyde, and an Amine
Posted on 2012-06-01 - 00:00
A novel microwave-assisted approach for the one-pot Cu(I)-catalyzed
A3-coupling/decarboxylative coupling (PA2-coupling)
of a propiolic acid, an aldehyde, and an amine, resulting in the formation
of diversely substituted 1,4-diamino-2-butynes, is described. It is
noteworthy that this new multicomponent coupling provides an efficient
access to introduce alkyl and aryl group at the 1,4-position of the
1,4-diamino-2-butynes.
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Feng, Huangdi; Ermolat’ev, Denis S.; Song, Gonghua; V. Van der Eycken, Erik (2016). Synthesis of Symmetric
1,4-Diamino-2-Butynes via a Cu(I)-Catalyzed One-Pot A3-Coupling/Decarboxylative
Coupling of a Propiolic Acid, an Aldehyde, and an Amine. ACS Publications. Collection. https://doi.org/10.1021/jo300562j
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