Synthesis of Enantioenriched α,α-Dichloro-
and α,α-Difluoro-β-Hydroxy Esters and Amides by
Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation
Posted on 2018-08-09 - 19:39
A mild and convenient approach was
developed to prepare a series
of α,α-dihalogeno β-hydroxy esters or amides by
using commercially available Noyori’s complex [RuCl(p-cymene)(R,R)-TsDPEN]
as a catalyst (S/C = 100−200) in the asymmetric transfer hydrogenation
of the corresponding ketones. Moderate to high yields (up to 99%)
and excellent enantioselectivities (up to >99% ee) were achieved
for
a series of variously substituted dichloro and difluoro β-hydroxy
esters and amides.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Zheng, Long-Sheng; Phansavath, Phannarath; Ratovelomanana-Vidal, Virginie (2018). Synthesis of Enantioenriched α,α-Dichloro-
and α,α-Difluoro-β-Hydroxy Esters and Amides by
Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b01943
or
Select your citation style and then place your mouse over the citation text to select it.