Synthesis of Amino-Substituted α- and δ‑Carbolines
via Metal-Free [2 + 2 + 2] Cycloaddition of Functionalized Alkyne-Nitriles
with Ynamides
Posted on 2019-02-08 - 20:45
A metal-free
[2 + 2 + 2] cycloaddition of alkyne-cyanamides or
ynamide-nitriles with ynamides is described for the efficient synthesis
of amino-substituted α- and δ-carbolines. This novel methodology
is environmentally friendly and allows for highly regioselective access
to carboline derivatives in good to excellent yields with wide functional
group tolerance.
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Zhang, Jingyi; Guo, Meichao; Chen, Yajuan; Zhang, Shuangshuang; Wang, Xiao-Na; Chang, Junbiao (2019). Synthesis of Amino-Substituted α- and δ‑Carbolines
via Metal-Free [2 + 2 + 2] Cycloaddition of Functionalized Alkyne-Nitriles
with Ynamides. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.9b00021
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AUTHORS (6)
JZ
Jingyi Zhang
MG
Meichao Guo
YC
Yajuan Chen
SZ
Shuangshuang Zhang
XW
Xiao-Na Wang
JC
Junbiao Chang