Synthesis of Amino-Substituted α- and δ‑Carbolines via Metal-Free [2 + 2 + 2] Cycloaddition of Functionalized Alkyne-Nitriles with Ynamides

Published on 2019-02-08T20:45:29Z (GMT) by
A metal-free [2 + 2 + 2] cycloaddition of alkyne-cyanamides or ynamide-nitriles with ynamides is described for the efficient synthesis of amino-substituted α- and δ-carbolines. This novel methodology is environmentally friendly and allows for highly regioselective access to carboline derivatives in good to excellent yields with wide functional group tolerance.

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Zhang, Jingyi; Guo, Meichao; Chen, Yajuan; Zhang, Shuangshuang; Wang, Xiao-Na; Chang, Junbiao (2019): Synthesis of Amino-Substituted α- and δ‑Carbolines

via Metal-Free [2 + 2 + 2] Cycloaddition of Functionalized Alkyne-Nitriles

with Ynamides. ACS Publications. Collection.