Synthesis of 3,3-Dihalogenated 2‑Aminochromanones via Tandem Dihalogenation and Cyclization of o‑Hydroxyarylenaminones with NXS (X = Cl or Br)

Posted on 14.10.2021 - 06:13
An unprecedented method for the synthesis of dichlorinated and dibrominated 2-amino-substituted chromanones is developed by employing enaminones and NCS/NBS as starting materials under microwave irradiation. The reactions proceed quickly to deliver products without using any catalyst or additive, thus providing practical access to 3,3-dihalogenated 2-aminochromanones.

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Luo, Tian; Wu, Haozhi; Liao, Li-hua; Wan, Jie-Ping; Liu, Yunyun (2021): Synthesis of 3,3-Dihalogenated 2‑Aminochromanones via Tandem Dihalogenation and Cyclization of o‑Hydroxyarylenaminones with NXS (X = Cl or Br). ACS Publications. Collection. https://doi.org/10.1021/acs.joc.1c01851
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