Synthesis of 2‑Formylpyrroles from Pyridinium
Iodide Salts

Chen, Hua

Synthesis of 2‑Formylpyrroles from Pyridinium Iodide Salts

Posted on 2020-07-17 - 16:33

The first I₂-mediated synthesis of 2-formylpyrroles from pyridinium salts is reported. This protocol enables the synthesis of diversely substituted 2-formylpyrroles in good yields under operationally simple conditions. The detailed mechanistic studies reveal that the reaction proceeds via a novel H₂O-triggered ring opening of the pyridinium salt and a subsequent intramolecularly nucleophilic addition sequence.

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Xu, Ke; Li, Wenjing; Sun, Rui; Luo, Lihua; Chen, Xue; Zhang, Chunchun; et al. (2020). Synthesis of 2‑Formylpyrroles from Pyridinium Iodide Salts. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c02178

https://doi.org/10.1021/acs.orglett.0c02178

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