Synthesis and Evaluation of Antimicrobial and Antibiofilm Properties
of A‑Type Procyanidin Analogues against Resistant Bacteria
in Food
Posted on 2018-02-20 - 22:14
Natural
A-type procyanidins have shown very interesting biological
activities, such as their proven antiadherence properties against
pathogenic bacteria. In order to find the structural features responsible
for their activities, we describe herein the design and synthesis
of six A-type procyanidin analogues and the evaluation of their antimicrobial
and antibiofilm properties against 12 resistant bacteria, both Gram
positive and Gram negative, isolated from organic foods. The natural
A-type procyanidin A-2, which had known antiadherence activity, was
also tested as a reference compound for the comparative studies. Within
the series, analogue 4, which had a NO2 group
on ring A, showed the highest antimicrobial activity (MIC of 10 μg/mL)
and was one of the best molecules at preventing biofilm formation
(up to 40% decreases at 100 μg/mL) and disrupting preformed
biofilms (up to 40% reductions at 0.1 μg/mL). Structure–activity
relationships are also analyzed.
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Alejo-Armijo, Alfonso; Glibota, Nicolás; Frías, María P.; Altarejos, Joaquín; Gálvez, Antonio; Salido, Sofía; et al. (2018). Synthesis and Evaluation of Antimicrobial and Antibiofilm Properties
of A‑Type Procyanidin Analogues against Resistant Bacteria
in Food. ACS Publications. Collection. https://doi.org/10.1021/acs.jafc.8b00535
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AUTHORS (7)
AA
Alfonso Alejo-Armijo
NG
Nicolás Glibota
MF
María P. Frías
JA
Joaquín Altarejos
AG
Antonio Gálvez
SS
Sofía Salido
EO
Elena Ortega-Morente