Synthesis and Characterization of sn Inclusion Complex
of dl-Aminoglutethimide with β‑Cyclodextrin
and Its Innovative Application in a Biological System: Computational
and Experimental Investigations
Posted on 2022-03-28 - 17:38
Our present study
intended to investigate the encapsulation of
DL-AGT within the lipophilic cavity of a β-CD molecule. The
consequential inclusion system was characterized by UV–visible
spectroscopy and 1H NMR, PXRD, SEM, and FT-IR studies.
Molecular docking was performed for the inclusion complex to discover
the most proper orientation, and it was seen that the drug DL-AGT
fits into the cavity of β-CD in a 1:1 ratio, which was also
confirmed from the Job plot. Furthermore, a comparison was done on
the basis of cell viability between the drug and its inclusion complex.
CITE THIS COLLECTION
DataCite
No result found
Ray, Samapika; Roy, Niloy; Barman, Biraj Kumar; Karmakar, Paramita; Bomzan, Pranish; Rajbanshi, Biplab; et al. (2022). Synthesis and Characterization of sn Inclusion Complex
of dl-Aminoglutethimide with β‑Cyclodextrin
and Its Innovative Application in a Biological System: Computational
and Experimental Investigations. ACS Publications. Collection. https://doi.org/10.1021/acsomega.2c00011
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
AUTHORS (10)
- SRSamapika RayNRNiloy RoyBBBiraj Kumar BarmanPKParamita KarmakarPBPranish BomzanBRBiplab RajbanshiVDVikas Kumar DakuaADAnkita DuttaAKAnoop KumarMRMahendra Nath Roy
