Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazoline,
1,3-Thiazolidine, and 1,2,4-Triazoline Double-Tailed Acyclo C‑Nucleosides

Abdelrehim, El-Sayed M.

Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazoline, 1,3-Thiazolidine, and 1,2,4-Triazoline Double-Tailed Acyclo C‑Nucleosides

Posted on 2022-05-14 - 18:03

The condensation products of terphthaloyl bishydrazide with two equivalents of various monosaccharide aldoses were found to have a bis(sugarhydrazone) form or bis-glycosylhydrazide structure or coexist in tautomeric equilibrium depending on the sugar configuration. The condensation products were substantially utilized as 3-acetyl-1,3,4-oxadiazoline, 1,3-thiazolidine, and 4-amino-1,2,4-triazoline double-tailed acyclo C-nucleosides synthons. The preliminary antimicrobial activities of representative examples of the prepared compounds were evaluated.

CITE THIS COLLECTION

Nasr, Adel Z.; Farahat, Abeer; Zein, Mohamed A.; Abdelrehim, El-Sayed M. (2022). Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazoline, 1,3-Thiazolidine, and 1,2,4-Triazoline Double-Tailed Acyclo C‑Nucleosides. ACS Publications. Collection. https://doi.org/10.1021/acsomega.1c06339

https://doi.org/10.1021/acsomega.1c06339

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