Striking Effect of Polymer End-Group on C60 Nanoparticle Formation by High Shear Vibrational Milling with Alkyne-Functionalized
Poly(2-oxazoline)s
Version 2 2019-02-11, 15:21
Version 1 2019-01-23, 20:17
Posted on 2019-02-11 - 15:21
Buckminsterfullerene
(C60) has a large potential for
biomedical applications. However, the main challenge for the realization
of its biomedical application potential is to overcome its extremely
low water solubility. One approach is the coformulation with biocompatible
water-soluble polymers, such as poly(2-oxazoline)s (PAOx), to form
water-soluble C60 nanoparticles (NPs). However, uniform
and defined NPs have only been obtained via a thin film hydration
method or using cyclodextrin-functionalized PAOx. Here, we report
the mechanochemical preparation of defined and stable C60:PAOx NPs by the introduction of a simple alkyne group as a polymer
end-group. The presence of this alkyne bond is proven to be crucial
in the mechanochemical synthesis of stable, defined sub-100 nm C60:PAOx NPs, with high C60 content up to 8.9 wt
%.
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Van Guyse, Joachim
F. R.; de la Rosa, Victor R.; Lund, Reidar; De Bruyne, Michiel; Rycke, Riet De; Filippov, Sergey K.; et al. (2019). Striking Effect of Polymer End-Group on C60 Nanoparticle Formation by High Shear Vibrational Milling with Alkyne-Functionalized
Poly(2-oxazoline)s. ACS Publications. Collection. https://doi.org/10.1021/acsmacrolett.8b00998
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AUTHORS (7)
JV
Joachim
F. R. Van Guyse
Vd
Victor R. de la Rosa
RL
Reidar Lund
MD
Michiel De Bruyne
RR
Riet De Rycke
SF
Sergey K. Filippov
RH
Richard Hoogenboom