Slicing and Splicing of Bromodifluoro‑N‑arylacetamides: Dearomatization and Difunctionalization
of Pyridines
Posted on 2020-08-01 - 15:29
Copper-catalyzed
dearomatization and difunctionalization of pyridines have been disclosed,
in which bromodifluoro-N-arylacetamide was sliced
into five fragments and three or four of them were transferred to
pyridine partners. Through this reaction, novel N-difluoromethyl-2-imine dihydropyridine derivatives can be conveniently
accessed from commercially available 4-amino substituted pyridines.
This strategy demonstrates a novel fluorination method featuring high
atom economy, environmental friendliness, an easily available catalyst,
and simple operation.
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Chen, Hongtai; Yang, Yanyan; Wang, Lianxin; Niu, Yuxiang; Guo, Minjie; Ren, Xiangwei; et al. (2020). Slicing and Splicing of Bromodifluoro‑N‑arylacetamides: Dearomatization and Difunctionalization
of Pyridines. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c02368
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AUTHORS (9)
HC
Hongtai Chen
YY
Yanyan Yang
LW
Lianxin Wang
YN
Yuxiang Niu
MG
Minjie Guo
XR
Xiangwei Ren
WZ
Wentao Zhao
XT
Xiangyang Tang
GW
Guangwei Wang