Series of Functionalized
5‑(2-Arylimidazo[1,2‑a]pyridin-3-yl)pyrimidine-2,4(1H,3H)‑diones: A Water-Mediated Three-Component
Catalyst-Free
Protocol Revisited
Posted on 2020-06-15 - 18:04
A water-mediated
and catalyst-free practical method for the synthesis
of a new series of pharmaceutically interesting functionalized 5-(2-arylimidazo[1,2-a]pyridin-3-yl)pyrimidine-2,4(1H,3H)-diones has been accomplished based on a one-pot multicomponent
reaction between arylglyoxal monohydrates, 2-aminopyridines/2-aminopyrimidine,
and barbituric/N,N-dimethylbarbituric
acids under reflux conditions. The salient features of this protocol
are avoidance of any additive/catalyst and toxic organic solvents,
use of water as reaction medium, clean reaction profiles, operational
simplicity, ease of product isolation/purification without the aid
of tedious column chromatography, good to excellent yields, and high
atom-economy and low E-factor.
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Brahmachari, Goutam; Nayek, Nayana; Karmakar, Indrajit; Nurjamal, Khondekar; Chandra, Swapan K.; Bhowmick, Anindita (2020). Series of Functionalized
5‑(2-Arylimidazo[1,2‑a]pyridin-3-yl)pyrimidine-2,4(1H,3H)‑diones: A Water-Mediated Three-Component
Catalyst-Free
Protocol Revisited. ACS Publications. Collection. https://doi.org/10.1021/acs.joc.0c00732