Self-Healable Porous Polyampholyte Hydrogels with
Higher Water Content as Cell Culture Scaffolds for Tissue Engineering
Applications
Posted on 2020-07-22 - 19:09
In
this paper, we first demonstrate the control of the film pore
size using neutral hydrophilic 2-hydroxyethyl methacrylate (HEMA)
content. To improve the mechanical properties of a polyampholyte (PA),
both HEMA and the cross-linker N,N′-methylenebisacrylamide (Bis-Am) were introduced into the
PA chain. The predesigned copolymers showed great mechanical properties
and optical behavior. The introduction of HEMA significantly increased
the water content of the polymer, leading to the formation of porous
structures in xerogels. The dynamic interaction between the positive
and negative termini of the PA endowed the hydrogels with self-healing
ability. The synthesized chemically cross-linked PA gels showed high
stability in saline solution. The biocompatibility of the PA gels
was confirmed using a cytotoxicity test of cells attached to the synthesized
PA-X-2 and PA/HEMA-90/10-X-0.5. The results of this investigation
indicate that the synthesized PA gels are applicable as a polymeric
scaffold for cell culture.
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Liu, Jui-Hsiang; Hung, Yi-Hua; Chang, Kai-Ti; Kao, Chun-Yu; Lin, Yu-Ting; Liu, Chun-Yen (2020). Self-Healable Porous Polyampholyte Hydrogels with
Higher Water Content as Cell Culture Scaffolds for Tissue Engineering
Applications. ACS Publications. Collection. https://doi.org/10.1021/acsabm.0c00757
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AUTHORS (6)
JL
Jui-Hsiang Liu
YH
Yi-Hua Hung
KC
Kai-Ti Chang
CK
Chun-Yu Kao
YL
Yu-Ting Lin
CL
Chun-Yen Liu