Selective Lithiation, Magnesiation, and Zincation
of Unsymmetrical Azobenzenes Using Continuous Flow

Knochel, Paul

Selective Lithiation, Magnesiation, and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow

Posted on 2017-03-15 - 16:34

A mild and general set of metalation procedures for the functionalization of unsymmetrical azobenzenes using a commercially available continuous-flow setup is reported. The metalations proceed with TMPLi under convenient conditions (0 °C, 20 s), and various classes of electrophiles can be used. With sensitive substrates, an in situ trapping metalation in which TMPLi is added to a mixture of the azobenzene and ZnCl₂ or MgCl₂·LiCl was very effective for achieving high yields.

CITE THIS COLLECTION

Ketels, Marthe; Konrad, David B.; Karaghiosoff, Konstantin; Trauner, Dirk; Knochel, Paul (2017). Selective Lithiation, Magnesiation, and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b00460

https://doi.org/10.1021/acs.orglett.7b00460

or

Select your citation style and then place your mouse over the citation text to select it.