Regioselective Hydroboration and Hydrosilylation of N‑Heteroarenes Catalyzed by a Zinc Alkyl Complex
Posted on 2020-07-06 - 18:04
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available zinc alkyl complexes showed good activity and
regioselectivity in catalyzing hydroboration and hydrosilylation of
N-heteroarenes. Hydroboration of benzo-fused N-heterocycles gave exclusive
1,2-addition products in 80–97% yields. Reactions of pyridines
afforded a mixture of 1,2-, 1,4-,
and 1,6-products in yields of 55–95%, with 1,2-dihydropyridine
as the main product. Bis-hydrosilylation
was observed for quinoline derivatives, generating bis-1,2-hydrosilylation
products in 76–96% yields. Kinetic studies and control experiments
were conducted to
gain some insights into the reaction mechanism.
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Wang, Xinxin; Zhang, Yu; Yuan, Dan; Yao, Yingming (2020). Regioselective Hydroboration and Hydrosilylation of N‑Heteroarenes Catalyzed by a Zinc Alkyl Complex. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c02082
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AUTHORS (4)
XW
Xinxin Wang
YZ
Yu Zhang
DY
Dan Yuan
YY
Yingming Yao